Mesotherapy or Profhilo – Which treatment is right for you?
When it comes to non-surgical skin rejuvenation, both Mesotherapy and Profhilo® are among the most popular treatments. Both methods improve skin quality, but they differ significantly in their mode of action and treatment goals.

The Mesotherapy Face is based on the targeted injection of a specially tailored cocktail of active ingredients. Vitamins, amino acids, antioxidants, minerals, and hyaluronic acid are delivered directly into the middle layer of the skin.
The aim is to intensively moisturize the skin, stimulate cell metabolism, and make the complexion visibly fresher.
Profhilo® on the other hand, takes a different approach. It uses highly pure hyaluronic acid, which spreads widely in the tissue and stimulates the natural production of collagen and elastin. This primarily improves skin firmness and elasticity.
When is Mesotherapy the better choice?
Mesotherapy is particularly suitable for people,
- whose skin is dry or dehydrated,
- who have a tired or dull complexion,
- who want to reduce first fine lines,
- who want to improve their skin quality long-term,
- who desire a natural glow.
Especially younger patients often opt for mesotherapy to prevent the first signs of skin aging.
When is Profhilo more suitable?
Profhilo® is often recommended when there is already visible loss of elasticity or sagging skin. Due to the intensive stimulation of collagen and elastin production, the treatment is particularly suitable for the face, neck, and décolleté.
Depending on the findings, a hyaluronic acid injection in the décolleté to improve skin moisture or a Botox treatment for neck wrinkles (platysma) to reduce expression lines may also be advisable. The most suitable treatment is decided individually during a consultation.
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Mesotherapy or PRP Treatment (Vampire Lifting) – What are the differences?
Both mesotherapy and PRP treatment (Vampire Lifting) are among the most popular minimally invasive methods of skin rejuvenation. Although both procedures can improve the complexion, they differ significantly in terms of their active ingredients and their biological effects. In mesotherapy, specially developed combinations of active ingredients are injected directly into the skin. The aim is to intensely moisturize the skin with vitamins and antioxidants and to support its natural regeneration. In contrast, a PRP treatment involves taking a small amount of the patient's own blood. After preparation, the platelet-rich plasma is injected into the skin. The growth factors contained can promote the body's own collagen production and support regeneration processes.
When is Mesotherapy suitable?
Mesotherapy is particularly suitable for:
- dry skin,
- dull complexion,
- fine lines,
- first signs of aging,
- tired skin.
When is PRP treatment useful?
PRP is particularly suitable for individuals who want to activate their natural skin regeneration. PRP can also be a useful treatment option for acne scars or declining skin quality.
Can Mesotherapy be combined with PRP?
Yes. Both procedures often complement each other very well. While PRP stimulates regenerative processes, mesotherapy improves the skin's supply of valuable nutrients. This allows both treatments to support each other.
Mesotherapy or Polynucleotides (Salmon DNA) – Which treatment is better for your skin?
Polynucleotides (Salmon DNA) are among the modern biostimulators and are increasingly used for skin regeneration. Although both mesotherapy and polynucleotides can improve skin quality, both treatments pursue different goals.
Mesotherapy specifically supplies the skin with vitamins, hyaluronic acid, and other active ingredients to provide moisture and visibly revitalize the complexion.
Polynucleotides, on the other hand, primarily act at a cellular level. They support natural repair processes in the tissue and promote skin regeneration. This can lead to long-term improvements in elasticity, skin structure, and firmness.
When is Mesotherapy more suitable?
Mesotherapy is often the right choice for:
- dry skin,
- first wrinkles,
- dull complexion,
- dehydrated skin,
- prevention of skin aging.
When are Polynucleotides useful?
Polynucleotides are particularly suitable for:
- mature skin,
- loss of elasticity,
- sensitive skin,
- skin in need of regeneration,
- sagging tissue.
Can both treatments be combined?
Yes. Depending on the skin condition, a combination can be beneficial. While polynucleotides promote skin regeneration, mesotherapy improves skin hydration and provides a fresh glow. An individual treatment plan helps determine the optimal therapy.